TOKYO (AP) — Shares were mixed in Asia on Wednesday, as weak data from China sapped upward momentum from an overnight rally on a flurry of deals in the pharmaceutical sector.

A preliminary survey of Chinese manufacturers by HSBC showed slight improvements in prices and demand, but contractions in new export orders and employment in April. The results were expected, but helped pull Hong Kong’s Hang Seng index down 0.6 percent to 22,592.41. Shares in mainland China also fell.