Senators are set to work through the weekend in order to confirm or advance several of President Donald Trump’s nominees and overcome efforts by Democrats to delay using procedural hurdles.

Negotiations broke down Tuesday evening between Democrats and Republicans to hold a final vote on John Ratcliffe to be CIA director, prompting GOP leadership to tee up procedural steps to advance Ratcliffe, Gov. Kristi Noem (R-SD) to be homeland security secretary, and Pete Hegseth to be defense secretary.